Chapter 6 Video Q Essay Example for Free

Chapter 6 Video Q EssayThis video addresses business etiquette in a divided up workspace. Go to www. mystudentsuccesslab. com or your course website, watch this video again, and answer the following questions 1 Were Brian, John, and Joe acting appropriately at the start of the video? Why or why not? No. Brian, John and Joe were not acting appropriately. They were being rude and disrespectful while Regina was trying to meet her deadline. 2 When is it appropriate to usurp another persons desk items? It is only appropriate to borrow a coworkers item when you ask for permission. 3 Is Brian dressed appropriately? Why or why not? No, his shirt wasnt tucked in and he was dressed to casual for a business environment. 4 Is it appropriate for Joe to eat his homemade filthy nutriment in a shared work area? Why or why not? No, it was not appropriate for Joe to be alimentation his food in an undersigned area. Food should be consumed in the lunch room and only on break. The smell of the food could offend everyone in the office if you are eating it in a shared work area. 5 If you were the boss and walked in on this situation, what would you do?I would call all three of them employees into my office and demonstrate appropriate work behavior, and explain how their disruption effect others work performance. I would also warn them that if this behavior continued disciplinary actions would be taken upon them. 6 Assume you are Regina, and the next day you catch John rummaging through your desk. What should you do? I would immediately seek my supervisor. Although it would be easier to lambaste to him about the situation on a personal level, I wouldnt want any verbiage to be taken in the wrong context.

Caring for Individuals with Additional Needs Essay Example for Free

Caring for Individuals with Additional Needs EssayIn this task the explanation of why individuals may experience additional needs will be provided. There atomic number 18 4 main categories of disability. I will list them and also give an sample of each fellowship and also say if the disability is physical, cognitive or sensory. Physical meaning having problems with strength or co-ordination within caused by having an accident or an inspection. Cognitive meaning a person having problems with learning and understanding everyday things.Sensory this can be a problem with learning through sight, taste, smell, stir up and hearing. Basically this has to do with the five senses. The categories are Genetic (from a family member through blood) Sickle cell is contracted through either parent (mother/father) who has the trait. This trait can be passed on to the child or children. If the father has a trait and the mother has a trait, the child can get the full trait. This category is physical.Accidental accidents can cause disability e. g. a person driving a car and accidentally hits down a person walking in the road this can cause major damage to this person. The person could be paralyzed for life. This category is physical and could also be cognitive because this person could arrive at hit his/her head and ended up being brain damage. The brain damage can lead to this person losing most of the knowledge he/she had forward and have to start learning all over again.Developmental can be caused be a pregnant woman having difficulty in the uterus or during birth. A child can develop disability while growing up for example contracting Meningitis. Possible complications that can be caused are hearing loss, learning disability or problem with co-ordination and balance. This category can be sensory, physical or cognitive. Environmental can be caused by on the job(p) in a place where there is lots of dust or even smoking can cause a person to develop bronchial a sthma or other infections. This category can be physical.

Assignment Work Within A Legal And Efficical Time Frame Essay Example for Free

Assignment Work Within A Legal And Efficical Time Frame Essay1. Why is it all-important(a) for a executioner in the alliance run Industry to follow their pedigree description? Because we wee-wee a duty of care to our lymph glands and next our job description is the way we can give our clients the best way to provide a profession standard of service. And keeping in line with the polices kept in place by the government.2. Define the term policy.A policy are rules set out that need to be followed.3. Define the term modus operandi. A procedure is a step by step way of how a organisation achieves its desire goal.Why do Community run Industry get toers need to work within agency policy and procedures? Provide three (3) reasons.Ensure they do they do their job properlySo No unnecessary harm is caused to the clientTo provide a proper duty of care to the client4. Give five examples of areas that should be covered in a policy/procedure manual. occupational health and safetyDut y of careCommunicationMandatory Reporting (child abuse)Case management procedure5. Define the term legislation.Legislation are laws which have been enforced by the state or federal government.6. Define the term statutory requirements?An act that requires you to do something or not do something is a statutory requirement.7. Define the term regulatory requirements?Regulatory requirements are rules that tell you how a service should be run.8. List three pieces of legislation impacting on the Community Services Industry and state the purpose of each. Legislation has the word Act in the title.9. When gathering personal information from a client, what do you need to tell them? lying-in BCase StudyRead the following case learningYou are a family and community worker employed by a community-based organisation that is located in a commonplace housing estate. You have been working with the following family for a number of months. Julie has four children, aged 2-10 years old, and lives in a public housing estate in Springvale. You became involved with Julies family when she moved to the estate, having left Bill, the father of her children, referable to experiencing domestic violence. Julie was granted public housing due to her single parent status, and she is receiving Parenting Payment (Single) from Centrelink. She was referred to your service, regarding her issues of isolation and parenting difficulties with her elder children. The focus of your intervention has been supporting Julie in her parenting role, linking her with community resources and developing budgeting skills. Julie has never been notified to the state child shelter services for suspected abuse of her children.During recent visits, you are becoming increasingly concerned about Julies lifestyle. Arriving at Julies place in the morning, the level(p)is in truth chaotic, the older kids are always rushing off late to school, and the flat is very messy, with unwashed dishes and scraps of food lying aroun d. The younger children calculate to always be watching TV and there is evidence of heavy drinking the night before. On your last visit, Julie informed you that Bill was moving in with her and the kids. Despite Bills heavy drinking, Julie is very lonely and not coping with the kids well on her own.She plans to keep this a secret from Centrelink and the state public housing department, as she may no longer be eligible for her financial benefits or subsidised housing. While you acknowledge Julies feelings of isolation, you are very concerned for the childrens safety if Bill returns to the family home. You decide that you need to discuss some of these recent developments with Julie. You are aware that Bill is very anti-community workers and may play off very negatively if he is there when you turn up. He has a history of bullying and threatening behaviour with community agencies that have assisted the family in the past.Answer the following questions based on the case study1. How wou ld you find out what your roles and responsibilities are as a family worker?2. In this case study what would be your roles and responsibilities as the worker?3. Consult the attached Job Description. From the job description state three (3) key responsibilities and discuss how you could apply each of the responsibilities to this family.4. As the worker, identify and discuss two (2) ethical dilemmas in this case study. You need to state the ethical dilemmas from the learning material and discuss why it could be a dilemma for you as a worker.5. What principles of ethical decision making would you need to be aware of when dealing with the ethical dilemmas you identified, and why?6. Identify the factors that contribute to fortune of harm of the children in this case study.7. Identify and discuss your duty of care in relation to each family member?8. If you were unsure about how to proceed in working with this family, what would you do next?Read the next part of the case study and answer the following questions In the course of your work with Julie and her family, Julie expresses dissatisfaction about your work with her family. She is adamant that you have a vendetta against Bill, and that you have breached her confidentiality by discussing her situation with other services (such as Centrelink) and is accusing you of acting unprofessionally.9. Identify Julies rights in this situation.10. Identify the legislation that supports client complaints in this industry. Legislation has the word Act in the title.11. Discuss how you would deal with Julies complaint.Task CAnswer the following questions1. From the learning material, identify a model for working through issues and dealing with ethical dilemmas.2. From the learning material, identify the significant ethical guidelines in the Community Services Industry.3. From the learning material, identify ways that we can ensure client rights are upheld.4. From the learning material, identify the basic organisational procedure s that you will need to follow when managing a complaint.5. At what point would you consider using an advocate or an advocacy service?6. Define these termsAbuseNeglectRiskJob Description adjustFamily Support WorkerLocationSpringvale Community Services (SCS)ClassificationCommunity Services Worker Grade 3Social and Community Services Employees (State) giveHours of Duty Full time position 38 hrs/weekPosition ObjectivesTo support community, families and individuals as an advocate, point of referral and/or resource. Within OrganisationCompliance with Springvale Community Services Code of Conduct, Goals and Objectives, Mission Statement and Policies and Procedures Compliance with all relevant Legislation, Regulations and Awards Compliance with relevant government funding requirementsCompliance with individual grasp of practiceMaintain privacy and confidentiality of information within SCS Promote a positive image of SCSMaintain a commitment to SCSs Corporate inventLiaise with community service providers to plan and engage direct service provision Maintain effective communication and interpersonal skillsEfficient and effective employ of resources as allocated under the level of responsibility for the positionKey ResponsibilitiesProvide direct services to families and individuals that encompass, in consultation with the client(s), identification of issues/needs and implementation of a mutually agreed plan of referral and/or resource acquisition. Provide referral of clients to appropriate / specialist services as required At the request of the client, act as an advocate and/or support for clients accessing referral services and other agencies. Workwithin relevant legislation, regulations, codes of practice/conduct and organisational policy and procedures. Maintain factual and objective client records acknowledging the provision of the Privacy Act.Provide outreach services, as requiredSubmit monthly operational and statistical report to theCo-ordinator of Springvale Community Services Perform other duties as requested by theCo-ordinatorActively participate in weekly staff meetingsParticipate in and contribute to the overall Springvale Community Services Strategic scheme Provide a weekly planner at beginning of each week outlining activities relating to the position role to the Co-ordinator Maintain ongoing professional development ensuring cutting-edge knowledge of legislation, referral resources and current professional practicesReporting Relationships

Business Process Redesigning At Starbucks

Business Process Redesigning At StarbucksThis research paper discusses the reversal of the development momentum achieved by Starbucks confederation and the problems veneer its internal business process which in turn would decrease the node traveling bag of the familiarity in the long run. The paper draw offs some positive go to stall the dec aura by introducing redesigning in areas like information trunk for better inter fill and adding care for in its whole supply chain process. In order to be more approach effective in the whole of the pry chain of Starbucks the paper has introduced certain tools like lean circumspection and IT parcel to smoo consequently the process of interaction in a much better way.Starbucks Company has attained a unique place in the world for the brew and retailing of extra rich coffee experience that it gives to its millions of customers. The alliance has more than 16600 stores in over 40 countries and is still expanding. Starbucks sells differe nt varieties of coffee like knock off brewed coffee, espresso hot drinks, coffee beans, salads and other snacks, besides offering mugs and tumblers with its logo over the counter. Starbucks also runs an entertainment division and markets music and films apart from the sale of books and other stationery.Although Starbucks Company is seen to be the worlds largest producer and retailer of specialty coffee, offering the widest range of regular and decaffeinated coffee and beverages, it is not likely to be so in the future delinquent to stiff competition and price war. This means that most likely the competitors which are both local cafes and large retail giants are gaining ground in this recess area where Starbucks previously had a firm foothold. This is quite likely as the current trends of the worlds largest coffee brewer suggest and regardd the giant to terminal down shutters on many of its promising coffee stores around the world. The recession has further taken its toll with m any consumers preferring similar coffees at cheaper price. Therefore, there is every savvy to suggest that Starbucks carries out a total redesigning of its existing levels of functions right from the stage it procures its materials like raw bean purchase to the stage when the final out puzzle passes on to the r for each one of the customers at its various stores. This is not an insurmountable task as Starbucks own system has so far allowed it to function without much of hindrance. But given the detail that the current market conditions lease diversifyd drastically and the stiff competition has brought a price war, Starbucks would have to pretend some changes in the methods pertaining to this problem. Hence, this paper suggests certain authorized steps in the right direction which could make Starbucks a formidable challenge to it customers as wellhead as retain its large customer base almost intact. The first and primary step is to make some changes in the way the information system at Starbucks functions and the second is the way the lean concern system could be introduced in its protect chain starting from the procurance of raw materials to the sale of coffee beverages at its retail counters. In order to channel out the required focus on these two foremost activities it is necessary for Starbucks to introduce a newer and better Information System to solve this problem. This would mean that Starbucks would have to implement new package which helps in allowing the free flow of information with the complete supply chain process. As we move into the information age, the conquest of the organization depends upon its own experience and that of others and by the right method of collecting this information it attains the greatest competitive advantage (Fairfield, 2001). The second problem is to curtail wastages as well as avoid the fluctuating prices of coffee beans while procuring through a series of checks and pragmatic forecasting. The fluctuation i n prices could be seasonal and the procurement could be done by meticulous planning. For instance, coffee procurement could be make by coming into names with the suppliers on a long term basis where prices of coffee beans could be fixed. In this Starbucks is way ahead of all other competitors and posterior dictate terms in the market to some intent and thereby reduce its procurement embodys. For all this to be make into a seamless operation the rapid flow of information with the help of Internet and intranet is of paramount importance and hence the right software facilitating this flow for stage by stage implementation of lean direction and the consequent training of the staff for the fulfillment of the whole process are the prerequisites.Here, the Information System is quite different from the Information Technology and should not be confused. At Starbucks the information system includes the broker known as Information Technology and this is allowed to function in tandem w ith that of other processes in order to get the maximum effect.The Information system at Starbucks should achieve alignment of processes, the use of hardware, the installation of the requisite software and the relevant flow of data from one end of the value chain to the other. At Starbucks it is therefrom suggested that there should be a different approach for the flow of information and they must add value at every level of the supply chain. For this reason the staff ought to be trained in the right direction for understanding the whole processes at Starbucks in order to give the customers the best experience they can get anywhere else at affordable and competitive pricing. The information system at Starbucks can be made to use for procurement of supplies, the passing of the materials into the inventory, planning and cooking section and to the counter where the items pass into the hands of the customers.In order to make this operation smooth and almost effortless the staff must b e trained with skills in usage of the intranet and the Internet as well as lean management system. The basic creative thinker is to get everyone right from the procuring stage to the customer benefit section the knowledge and skills are required of lean management system. Not only this, the staff at each level of function adds something of value by carefully monitoring the items that pass through his or her hands and add value to it. The ultimate product when it reaches the hands of the customers is one of rich and impressive experience which the competitors would fail to do as it is Starbucks competitive strength. This culture once when imbued to all the areas of the Starbucks with the help of the fastest method in the form of unique software could become a marvel to its own employees as well as other stakeholders. The key determinant is how a carry is positioned and successful positioning involves associating the brand to the category which the customers can easily recognize a nd quickly differentiate (Iacobucci, 2001).Aligning Corporate Goal with Lean ManagementThe mission statement of Starbucks is to inspire and rear the human spirit and in fact means one person, one cup and one neighborhood at a time. The mission statement and so is quite ambitious for Starbucks and had not there been much of competition and every additional store that it established in one neighborhood made notes for it then the mission is quite in line with practicality. However, this is not so for Starbucks has to buckle under the pressure of world wide recession and many of its stores had to close down. In order for the mission statement and its objective are made practical Starbucks would have to implement the lean management system at each stage and to put that into affect it must have a smooth information flowing system in place. As lean management would put a check into the wastage apart from adding quality and value to the product at every stage it would allow the mission a nd the objectives of the company to be achieved without any hindrance. peradventure the lean management system being quite effective especially during crash crunch, there would be more liquidity infused into the system as well as there would be money available to fulfill the need for one store per neighborhood as per the mission statement. With proper checks in wastage through this system there would be better checks and controls over items that are not cost effective or which are not quite in line with Starbucks brand. Again, apart from quality the product looks and the way it is served should be appealing and this is also achieved by the staff who is involved in adding value to it. Product quality by itself does no make a sale for the customers must understand that the items they receive are of peachy quality and value (Reddy, 1994).Cost Benefits of Systems ChangeOne of the head factors for introducing lean management techniques at Starbucks is to control wastage and give prior ity to procurement of supplies and produce coffee beverages, snacks and other food products according to the demand. The software developed for the point would ensure the smooth function of the whole system so that neither there is any lag in quality of the product nor any wastage results out of it. In case of such careful alignment the functions of all departments in the supply chain remain uninterrupted and the end product attains a value that is truly an experience for the consumers. Again, by reducing the overall cost effectively the margins achieved are on the higher side and give the Starbucks Company the flexibility to counterfeit the price and if need be can reduce it significantly enough which is not at all possible for the competition.The other advantage is that during peak season there would be enough liquidity for expansion plans, especially in emerging economies where the affect of recession has not been felt so badly. So rase if the Starbucks management thinks of ex panding further it would not face resource crunch. But the best of all in this system is the bring to passance of staff which would be quite in line with mission statement of the company. The trained staff of Starbucks would be better placed in tackling any difficulties or problems and can be entrusted with even great responsibilities. The very culture would pave way for work life balance as a whole with total quality management being the focal point in the behavior of staff. Apart from that the employees would work in a more efficient manner as they would be rewarded and promoted based on the systems efficiency. whole these actions finally translate into increase customer service and further improve upon the customer service information by receiving feedbacks such that the system is again made more efficient and productive.Implementation of the SystemThe implementation of the lean management system could be made in a phased manner than in an unmannerly manner. The fact is that Starbucks has already got a system in place which is quite good as far as the standards are concerned. But this does not necessitate the system to be perfect as the cost effectiveness of its operation along with total quality control is of primary importance. However, while introducing a system over that of another or scrapping one altogether may not be quite to the liking of the employees and even managers as they would have already made themselves comfortable with the older system. Besides, they would not want another system to be thrust upon them for there is no written guarantee of sorts whether the new system would perform better or worse. Besides, it is quite a well known fact in the industrial circles that redesigning and reengineering have backfired on several well known companies. galore(postnominal) of these companies have had success over time only by and by several earlier attempts at reengineering had proved to be futile. This naturally brings all sorts of apprehensio n in the minds of the employees and they might resist these by deliberate acts of underperformance or vociferously. Hence, on its part the management should be aware of these changes and try to implement them in a phased manner. In many instances the employees as rightfully seen are the first target as they may be shifted or transferred or even asked to leave. This may be good for the company, but it surely upsets any employee who has given honest service to the company for many years. With the proper implementation of mechanisms that would address such issues the management may make the move for change in the system and introduce in a phased manner the lean system of management. They should also form an ideal mutually pleasant condition for this change and all employees are to be made aware of the fact that the customers nowa sidereal days are more discerning than ever before and if the company does not change or address this problem then it would have to down its shutter permanen tly. Customers are more discerning than they used to in the previous(prenominal) when they purchased simply depending upon their whims and fancies (Griffin, 2002). This sums up that the customer is the most important person at the premise of the stores of Starbucks and that the customer satisfaction should be the objective of the company policies and any change to that end has to be implemented whether it is acceptable to the employees and the management or not.The new system which would be implemented in a phased manner can be done within a stipulated compass point of time of one year. In order to implement the lean management system a good jump out plan is required and the management must ensure that the proper consider management software is used for the purpose. There are many types of software and the management as well as the other employees may be taken into confidence for the most suitable software after getting their feedback and response. The resulting software could b e chosen in consultation with a software company to suit the business. One of the prerequisite part of the project planning which actually relates to work schedules and the period of time that is required for their completion can be derived from a Gantt chart. These again can be developed with the help of a good software company or if it is to be used for each individual store then the same could be downloaded from various websites. Under the project plan the scope of the project is defined and then steps are taken and drafted for the completion of the same. That is various areas that require changes at Starbucks are stated and written down and these are then grouped in order the specific jobs could be allocated to individual employees. This can be more easily done with the help of a software schedule and the logical interrelationship between the different tasks like supplies, logistics, inventory, kitchen and counter can be very well defined with the help of a diagram skeletal or charted in the computer and then passed on to various stores with the help of the Internet. Here, the management as well as the employees can quickly get an idea of the important parts of the system as well as their most critical areas.With the help of this project planning Starbucks management can estimate the cost of resources that are necessary under the lean management system and the cost of implementation of each type of activity. This would enable them to get the total project cost and which again would lead to trimming and pruning of the budgetary allowances and the cost of implementation by foregoing some areas while making the necessary changes in the others. stopping pointThe Starbucks systems change by introducing lean management with the supplementary help from flow of information can be made into an effective tool for the overall growth of the organization, especially in retaining its large customer base and getting new ones. The system which is almost foolproof in nat ure is a concerted action on part of all level of employees and stakeholders in the supply chain. This redesign mitigates most of the fear that would have arisen had Starbucks lost a good number of its customers to its competitors. The find of losing business is in fact greatly curtailed and Starbucks can look forward to a complete turnaround in its profitability and share value after the system is made operational.One of the most important factors in this type of lean management technique is the overall focus which would make the staff and the management even more involved as their benefits would soon be perceived at all stages of the company. There would be no paucity of funds for day to day operation or if Starbucks had wanted to introduce an item on no profit or no loss basis for creating more value and goodwill then the same could be done without much affect on the overall profits of the company. The introduction of kiosks and digital retailing solutions and self service kiosk s which could be established anywhere could be implemented as they are all a perfect match to the system of lean management.

Hybrid Pharmacophores as Anti-inflammatory Agents

Hybrid Pharmacophores as Anti-inflammatory AgentsCHAPTER VIISUMMARY AND CONCLUSIONThe Synthesis of molecules that be important in the control of ageing diseases is very important in the expose decades. The obscures like Diarylsulfonylurea-chalcone may act as anti-inflammatory agents that may be linked as network to several diseases.The synthetic compounds have the abilities to act as preventive compounds having therapeutic action. In the present decade, one can control synthetic products in preventing aging diseases via anti-inflammation. Hence there is a need to discover story synthetic compounds that are deemed in prevention and treatment of diseases demo tremendous impact on health care systems.As a part of our research program aimed at search for new hybrid pharmacophores as anti-inflammatory agents, we are interested to have ,-unsaturatedketone linker to the diarylsulfonylurea basic nucleus to give a series of diarylsulfonylurea-chalcone hybrids. Therefore, in the present study an attempt has been made to design, combine and characterize some new diarylsulfonylurea-chalcone hybrids.Drug Discovery and dose development is a knowledge base, expensive and time intense method. Scientific advancements throughout the bygone 20 years have modified the manner pharmaceutical analysis generate novel bioactive molecules. Advances in machine/computer aided techniques and in reduplicate support of hardware have enabled in silico strategies, and particularly structure-based drug style technique, to speed up new target choice through identification of hits for the optimisation of lead compounds within the drug discovery method. Genomics, proteomics, bioinformatics and, chemo informatics have gained vast quality Associate in development became an integral a part of the commercialised and educational analysis, directive drug style and discovery. Virtual coating emerged as a crucial tool in our quest to access novel drug like compounds (Wermuth et al., 1998, All en, 2002).Rational in silico drug style are often tired 2 ways in which ligand-based or structure-based are analyzed for compound occupation. With the supply of the 3D structure of a biological target, its possible to use a structure-based approach to judge and predict the binding mode of a egress inside the situation of the receptor with tying up strategies. Currently its a well-liked technique used for increasing the speed of drug coming up with method. This was created attainable by the supply of the many super molecule structures that helped in developing tools to know the structure operate relationships, machine-controlled tying up and practical(prenominal) screening. Moreover, once no 3D structural data regarding target proteins with their receptor website is obtainable ligand-based style is applied. The ligand-based approach starts with a bunch of ligands binding to a like receptor with a similar mechanism. These four completely different methods supported the previous i nformation of the targets 3D structure and therefore the ligands binding to that square quantify predominant (Van, 2007 Kier, 1967).Chalcones are considered as precursors of flavonoidsand isoflavonoids in edible plants thatshowa variousarray ofmedical specialtyactivities. Chalcones are new folk of glycosidase (-amylase, -glucosidase, and -amylase) inhibitors that shows non-competitive inhibition acts against -glucosidase. The effect of chalcones in hyperglycemic-normal rats on serum glucose-lowering properties highlighting the novel compounds showing strong anti-hyperglycemic properties (Damazio et al., 2009).Sulfonylureas were only when drugs used to stimulate the insulin secretion in patients with type 2 diabetes or D2M. Diarylsulfonylurea (DSU) is a novel anticancer molecule because has funny chemical structure with broad-spectrum antisolid-tumor activity in preclinical models. The sulfonylurea inhibits the eosinophil survival in a method similar to lidocaine.Anti-inflammatio n is the biological process of the diseases that links to the pathways colligate to aging diseases. A substance that reduces inflammation are linked to cancer, diabetes, etc., are anti-inflammatory compounds used to reduce the risk of age related diseases.In the present investigation, the LPID approach is now applied to the database of 25 compounds virtually designed for finding best fit (hit identification) against selected anti-inflammatory protein drug target (5-Lipoxygenase (5-LO)). The compounds appear out of these molecular docking studies with least binding energy against target protein were prepared by using measuring conventional methods of synthesis and subjected for corresponding in vitro and in vivo studies. By this means, it is possible to understand how the compounds interact with the selected anti-inflammatory target protein. The results promising out of this study can be used to identify a new class of potential anti-inflammatory agents with selective 5-LO inhibit ory activity.A set of 25 diarylsulfonylurea-chalcone hybrids 4a-4y were subjected to ligand-protein inverse docking simulation using software Molegro Virtual Docker v 5.0. These compounds were docked against selected anti-inflammatory drug target (i.e. Human 5-Lipoxygenase PDB Code 3V99). The results of these studies could help in preliminary confirmation of inhibitory activity against 5-lipoxygenase. The result of the docking interactions between the selected compounds and protein target, data in shows that compound 4g was accomplished best binding efficiency against 5-lipoxygenase with Moldock Score (-193.641) with 3 hydrogen bond interactions and the corresponding interacting residues are Asn 554, Ser 608 and Ala 606 these hydrogen bonds not only relevant for the binding 4g to 3V99 to exhibit highly selective and potent binding affinity. Moreover, from the data given in it appears that the co-crystallized ligand arachidonic acid and positive standard abietic acid showed no hydrog en bond interactions with the active binding site residues indicating the importance of steric interactions and electrostatic interactions for their observed 5-lipoxygenase inhibitory activity.The key intermediary in the current study 1-(3-acetylphenyl)-3-tosylurea was synthesized by reaction of 3-aminoacetophenone with methylchloroformate under basic conditions at 0 C temperature to give methyl-3-acetylphenylcarbamate followed by the reaction with toluene sulphonamide and on the other hand subsequent Claisen-Schmidt densification of the intermediate with appropriate aromatic/heteroaromatic aldehydes in ethanolic KOH solution to give the corresponding diarylsulfonylurea-chalcone hybrids (4a4y) in good yieldThe investigation of the compounds(4a-4y) in vitro 5-LO inhibitory activity screening data revealed that the compounds 4r and 4o demonstrated comparatively the most potent inhibitory activity, with IC50 values of 7.880.14 g/mL and 11.770.21 g/mL, respectively.An in silico toxicit y tests can be conducted for diarylsulfonylurea-chalcone hybrids 4o, 4q, 4r, 4t, 4y and standard (Aceclofenac) to predict the toxicity nature using Lazar server. All the compounds are predicted as non-toxic. From the in vitro 5-LO inhibitory activity data, five potent diarylsulfonylurea-chalcone hybrids compounds (mentioned above) which displayed significant activity has been selected for further anti-inflammatory activity studies by using in vivo bioassay model i.e. Carrageenan-induced rat paw oedema method. The results of the assessment have been viewed by taking Aceclofenac as the standard drug.Finally the work concludes that all the compounds displayed were shown remarkable anti-inflammatory activity.

Ever At Odds: The Conflict and Reconciliation of Science and Religion in Paradise Lost and The Blazing World :: Paradise Lost Blazing World

Ever At Odds The Conflict and Reconciliation of Science and Religion in Paradise anomic and The Blazing WorldThroughout history, scientific theories and spiritual beliefs have often been at odds. Even today, most people are confront with the difficulty of reconciling their religious beliefs with modern science. In the 17th Century, when scientific thought was in its infancy and religion was the established source of knowledge around the universe, this conflict was of particular interest to writers and philosophers. Two similar but contrasting viewpoints on this issue can be seen in John Miltons Paradise Lost and Margaret Cav deceaseishs The Blazing World. Milton and Cavendish both see science as a tool for exploring the world however, while Milton feels that science can provide no deep perceptivity into Gods workings, Cavendish believes that science can potentially be a source of greater knowledge and understanding. Under the reign of Elizabeth I, England enjoyed a period of re ligious toleration. However, near the end of her reign, a growing religious minority, the Puritans, became increasingly critical of her policies, believing that she was still too close to Catholicism. These grievances were magnified when Elizabeths successor, James I, a devout Anglican, proved to be far less tolerant and tactful. Furthermore, James was accused of abusing his royal authority by attempting to undermine Parliament. The growing tension between Anglicans and Puritans worsened under James son, Charles I, who repeatedly angered a Parliament in which the House of Commons had gained a significant Puritan influence. In response, the Puritans, led by Oliver Cromwell, called for a reformation of the church, including the abolition of the Anglican Book of Common Prayer and a ban on bishops voting in the House of Lords. When Charles attempted to dispel the situation by clutch five Commons leaders, loyalties in the country split and the English Civil War began.Under Cromwells po litical and military leadership, the Puritan forces gained organization and determination. His New clay sculpture Army won a major battle in Naesby in 1645, which ultimately lead to Charles surrender. In January 1649, Charles I was executed and the Interregnum under Cromwell began. However, Cromwells reign was not successful, and by 1653 he was forced to rule through military dictatorship. After Cromwells death in 1660, Charles II was invited to crop from exile to claim the English throne. His return to power is known as the Restoration (Chambers 478-85).

jet propulsion :: essays research papers

Jet PropulsionPropulsion is a word that is derived from dickens Latin words pro meaning before or forwards and pellere meaning to drive. To push forward or drive an object forward is Propulsion. A propulsion system produces thrust to push an object forward. Newtons third law is the basis of the generation of thrust on airplanes. The locomotive accelerates a gas, and the reaction to this acceleration produces a force on the engine. Different propulsion systems generate thrust in slightly different ways. That is the propeller, the turbine engine, the ramjet, and the rocket. Each of these propulsion systems is employ everyday. The reason for four different types of engines is based on the balance of drag. Drag is what keeps planes in the air and accelerating. Thrust from the propulsion system must do 2 things balance the drag of the airplane when the airplane is cruising and also the thrust from the propulsion system must exceed the drag of the airplane for the plane to accelerate. Most airplanes snuff it most of their airtime cruising by means of the skies, such as cargo planes. In this application excess thrust is not as important as high engine efficiency and low fuel usage. Because of the aerodynamic efficiency of propellers and fans, it is more fuel efficient to accelerate a large mass by a dainty amount. That is why we find turboprops on cargo planes and airliners.Some aircraft such as fighter planes require very high thrust to accelerate quickly and to repress the high drag associated with high speeds of these airplanes, engine efficiency is not as important as very high thrust. Afterburning turbojets are used for this and a unexampled technology called ramjet or rocket propulsion is used for this.Well as you can see Propulsion is very important for flying through our skies.